Breast Cancer

A glimpse inside this collection:

Disparities in Care: Several articles address racial, ethnic, and socioeconomic disparities in breast cancer presentation, treatment options, and outcomes.
Treatment Strategies: Explore studies on neoadjuvant therapy, axillary nodal response, and potential alternatives to traditional breast surgery.
Patient Experience: Gain insights from research on postoperative complications, quality of life after treatment, and the psychological impact of breast cancer recurrence.
Emerging Technologies: Discover the potential of circulating microRNAs as diagnostic tools and the use of advanced technologies in breast cancer surgery.

We encourage you to explore these articles and gain a deeper understanding of the ongoing efforts to improve breast cancer diagnosis, treatment, and patient well-being.

Impact of Medicaid Expansion on Breast Cancer Diagnosis and Treatment in Southern States

Southern states that expanded the Affordable Care Act (ACA) had higher rate of Medicaid insurance and lower rate of distant breast cancer disease compared with states that did not expand ACA.

Evaluating the Role of Circulating MicroRNAs in Predicting Long-Term Survival Outcomes in Breast Cancer: A Prospective, Multicenter Clinical Trial

This prospective, multicenter trial recruited 124 patients undergoing neoadjuvant chemotherapy (NAC). MicroRNAs were were quantified from patient whole bloods using RQ-PCR during NAC. During NAC, increased miR-145 independently predicted improved recurrence- and disease-free survival.

Impact of Neoadjuvant Paclitaxel/Trastuzumab/Pertuzumab on Breast Tumor Downsizing for Patients with HER2+ Breast Cancer: Single-Arm Prospective Clinical Trial

The impact of abbreviated neoadjuvant regimens for HER2+ breast cancer on breast conservation therapy (BCT) is unclear. In a single-arm prospective trial of neoadjuvant paclitaxel/trastuzumab/pertuzumab for patients with stage II-III HER2+ disease, BCT rates were high at 55.4% overall and 81.8% among patients eligible for tumor downsizing.

Disparity in Breast Cancer Care: Current State of Access to Screening, Genetic Testing, Oncofertility, and Reconstruction

While advances in breast cancer treatment have led to improved survival over the past decades, disparity still exists. In this paper, disparity in screening, genetic testing, reconstruction, and oncofertility is examined.

Eliminating Breast Surgery for Invasive Cancer with Exceptional Response to Neoadjuvant Systemic Therapy: Prospective Multicenter Clinical Trial Planned Initial Feasibility Endpoint

This prospective, multicenter clinical trial demonstrates feasibility of omission of breast surgery for invasive triple-negative and HER2-positive cancer with exceptional response to neoadjuvant systemic therapy. No ipsilateral breast tumor recurrence was identified in the feasibility cohort (n=6) at a median follow-up of 44.3 months.

Long-Term Outcomes and Predictors of Response in Breast Cancer Patients with Advanced Nodal Involvement

In breast cancer patients with advanced nodal disease, excellent long-term outcomes can be achieved with trimodal therapy. While tumor response to neoadjuvant systemic therapy had the largest impact on survival, complete axillary nodal response was predictive of improved overall and event-free survival irrespective of breast response.

Breast Conservation Surgery for Breast Cancer in Men

Den, Jennifer; Nelson, Nicole; Khanipov, Kamil; et al

Impact of a 7-Gene Predictive Biosignature on Adjuvant Radiation Therapy Recommendations in Patients Undergoing Breast-Conserving Surgery for Ductal Carcinoma In Situ

Margenthaler, Julie A; Zoberi, Imran; Thomas, Maria; et al

Omitting Radiotherapy after Breast-Conserving Surgery in Luminal A Breast Cancer: The LUMINA Study

Laws, Alison; Brackstone, Muriel; Quan, May Lynn

Current Status of Contralateral Prophylactic Mastectomy: Investigating Structural Racial Disparity

Vadlakonda, Amulya BS; Curry, Joanna BA; Gao, Zihan MHSc; et al

Factors Predicting Overnight Admission after Same-Day Mastectomy Protocol and Associated Financial Implications

Caminiti, Nicholas MD; Maung, Aye Aye MS; Gaskins, Jeremy PhD; et al

Refractory and Recurrent Idiopathic Granulomatous Mastitis Treatment: Adaptive, Randomized Clinical Trial

Shojaeian, Fatemeh MD, MPH; Haghighat, Shahpar MD; Abbasvandi, Fereshteh MD; et al

Adherence Rate to Alliance for Clinical Trials in Oncology Z0011 Trial Based on Breast Cancer Subtype

Maramara, Taylor MD; Hsieh, Mei-Chin PhD; Janjua, Mahin MD; et al

Axillary Nodal Response to Neoadjuvant T-DM1 Combined with Pertuzumab in a Prospective Phase II Multi-Institution Clinical Trial

Weiss, Anna MD, FACS; Jin, Qingchun MPH; Waks, Adrienne G MD; et al

Novel Form of Breast Intraoperative Radiation Therapy with CT-Guided High-Dose-Rate Brachytherapy: Interim Results of a Prospective Phase-II Clinical Trial

Turkheimer, Lena M MD, MPH; Petroni, Gina R PhD; Berger, Adam C MD, FACS; et al

Association of High-Deductible Health Plans and Time to Surgery for Breast and Colon Cancer

Sheckter, Clifford C MD; Rochlin, Danielle H MD; Rubenstein, Robyn MD; et al

Ensuring Safety While Achieving Beauty: An Evidence-Based Approach to Optimizing Mastectomy and Autologous Breast Reconstruction Outcomes in Patients with Obesity

Hassan, Abbas M MD; Paidisetty, Praneet BS; Ray, Nicholas BS; et al

Delay and Disparity in Observed vs Predicted Incidence Rate of Screenable Cancer During the COVID-19 Pandemic

Romatoski, Kelsey S MD; Chung, Sophie H MD; Kenzik, Kelly MS, PhD; et al

Postoperative Complication Impact on Quality of Life after Postmastectomy Breast Reconstruction

Zhang, Chi MD; Gomez, Diego BS; Abdulwadood, Isra BS; et al

Breast Cancer Recurrence by Subtype in a Diverse, Contemporary Cohort of Young Women

Vuong, Brooke MD, MHA, FACS; Darbinian, Jeanne MS, MPH; Savitz, Alison MD, MBA, FACS; et al

Changes in Stage at Presentation among Lung and Breast Cancer Patients During the COVID-19 Pandemic

Mallouh, Michael BS, MSc; Linshaw, David MD; Barton, Bruce PhD; et al

Was It Worth It? Critical Evaluation of a Novel Outcomes Measure in Oncologic Palliative Surgery

Cohen, Joshua T MD; Beard, Rachel E MD, FACS; Cioffi, William G MD, FACS; Miner, Thomas J MD, FACS

Impact of Race, Ethnicity, Primary Language, and Insurance on Reconstruction after Mastectomy for Patients with Breast Cancer at an Urban, Academic Safety-Net Hospital

Beaulieu-Jones, Brendin R MD, MBA; Fefferman, Ann PhD; Woods, Alison P MD; et al

Impact of Preoperative Extramammary Findings in Patients with Newly Diagnosed Breast Cancer

Gleckler, Lauren MD; Roy, Nikita BS, MPH; Bernstein, Michelle BA; et al

Impact of Surgical Delay on Tumor Upstaging and Outcomes in Estrogen Receptor–Negative Ductal Carcinoma in Situ Patients

Deliere, Amanda E MD; Kuchta, Kristine M MS; Pesce, Catherine E MD, FACS; et al

Comparison of Wireless Localization Alternatives with Wire Localization for Nonpalpable Breast Lesions

Webster, Alexandra J BS; Kelly, Bridget N BA; McGugin, Caroline MD, MPH; et al

Area Deprivation Index and Rurality in Relation to Financial Toxicity among Breast Cancer Surgical Patients: Retrospective Cross-Sectional Study of Geospatial Differences in Risk Profiles

Corkum, Joseph MD, MSc; Zhu, Victor MD, MHS; Agbafe, Victor BA; et al

Racial and Ethnic Disparities in Surgical Outcomes after Postmastectomy Breast Reconstruction

Sarver, Melissa M BS; Rames, Jess D BS; Ren, Yi MS; et al

Prospective Evaluation of Radar-Localized Reflector–Directed Targeted Axillary Dissection in Node-Positive Breast Cancer Patients after Neoadjuvant Systemic Therapy

Gallagher, Kristalyn K DO, FACS; Iles, Kathleen MD; Kuzmiak, Cherie DO; et al

Outcomes of Breast-Conserving Surgery Plus Radiation vs Mastectomy for All Subtypes of Early-Stage Breast Cancer: Analysis of More Than 200,000 Women

Chu, Quyen D MD, MBA, FACS; Hsieh, Mei-Chin PhD; Yi, Yong PhD; et al

Podcast Episode

Episode 29: Refractory and Recurrent Idiopathic Granulomatous Mastitis Treatment: Adaptive, Randomized Clinical Trial

In this episode, Lillian Erdahl, MD, FACS, is joined by Fatemeh Shojaeian, MD, MPH, from the Johns Hopkins University School of Medicine. They discuss Dr Shojaeian’s recent article, “Refractory and Recurrent Idiopathic Granulomatous Mastitis Treatment: Adaptive, Randomized Clinical Trial,” in which the authors found that, for resistant or relapsing patients with idiopathic granulomatous mastitis, combining methotrexate and corticosteroids offers a promising strategy. This integration of disease-modifying antirheumatic drugs with corticosteroids not only reduces the necessity for high steroid doses but also effectively alleviates associated side effects.