Roux-en-Y Gastric Bypass Associated with Superior Long-Term Outcomes Compared with Sleeve Gastrectomy
March 4, 2025
Kraljevic M, Susstrunk J, Wolnerhanssen BK, et al. Long-Term Outcomes of Laparoscopic Roux-en-Y Gastric Bypass vs Laparoscopic Sleeve Gastrectomy for Obesity: The SM-BOSS Randomized Clinical Trial. JAMA Surg. 2025; in press.
This article reported outcomes (weight and metabolic, reoperation rates, quality of life) from a secondary analysis of the SM-BOSS randomized prospective trial comparing Roux-en-Y gastric bypass (n = 110) with sleeve gastrectomy (n = 107). All included patients from the four included Swiss bariatric centers were classified as severely obese prior to the index operation.
Data were available for at least 10 years following the index procedure. The data analysis showed that excess BMI loss was 65.2% for Roux-en-Y gastric bypass compared with 60.6% for sleeve gastrectomy. Patients undergoing sleeve gastrectomy had significantly higher reoperation rates due to insufficient weight loss and higher rates of gastroesophageal reflux.
The authors concluded that Roux-en-Y gastric bypass was associated with superior long-term outcomes compared with sleeve gastrectomy.
